論文 - 詳細
| RRC ID | 61385 |
|---|---|
| 著者 | Furutsu M, Kawashima K, Negishi Y, Endo H. |
| タイトル | Bidirectional effects of hypergravity on the cell growth and differentiated functions of osteoblast-like ROS17/2.8 cells. |
| ジャーナル | Biol Pharm Bull |
| Abstract |
A low level of hypergravity (1.5-2.0 G) stimulated the proliferation of ROS17/2.8 cells, whereas it inhibited the differentiated functions of alkaline phosphatase activity and osteocalcin synthesis. These results were just the opposite of our results obtained when the cells were exposed to a high level of hypergravity (40-80 G): inhibition of cell growth and the stimulation of the differentiated functions. The direction of change in the cAMP contents of the cells was also reversed, with a low level of hypergravity causing a decrease in the cAMP content and a high level of hypergravity an increase in it. Therefore, bidirectional effects of hypergravity on the growth and differentiated functions exist in ROS17/2.8 cells according to the magnitude of the hypergravity. |
| 巻・号 | 23(10) |
| ページ | 1258-61 |
| 公開日 | 2000-10-1 |
| DOI | 10.1248/bpb.23.1258 |
| PMID | 11041264 |
| MeSH | Alkaline Phosphatase / metabolism Animals Bone Neoplasms / pathology Cell Differentiation Cell Division Cell Line Cyclic AMP / metabolism Hypergravity / adverse effects* Osteoblasts / physiology* Osteocalcin / metabolism Osteosarcoma / pathology Rats Tumor Cells, Cultured |
| IF | 1.863 |
| リソース情報 | |
| ヒト・動物細胞 | ROS-17/2.8-5(RCB0462) |