| RRC ID |
61407
|
| Author |
Nguyen MTT, Nguyen KDH, Dang PH, Nguyen HX, Awale S, Nguyen NT.
|
| Title |
Calosides A-F, Cardenolides from Calotropis gigantea and Their Cytotoxic Activity.
|
| Journal |
J Nat Prod
|
| Abstract |
Phytochemical analysis of the roots of Calotropis gigantea led to the isolation of six new cardenolide glycosides, calosides A-F (1-6), and five known cardenolides (7-11). The structures of 1-6 were elucidated based on NMR and ECD spectroscopic data interpretation. Caloside D (4) is the first naturally occurring example of a cardenolide containing a C-8/C-19 oxygen bridge. In turn, calosides E (5) and F (6) represent the first naturally occurring 3-epi-cannogenol diglycosides having potent cytotoxicity against the PANC-1 cell line (IC50, 0.081 and 0.070 μM, respectively) and HeLa (IC50, both 0.17 μM) cells, under normoglycemic conditions.
|
| Volume |
83(2)
|
| Pages |
385-391
|
| Published |
2020-2-28
|
| DOI |
10.1021/acs.jnatprod.9b00875
|
| PMID |
31967821
|
| MeSH |
Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / pharmacology
Calotropis / chemistry*
Cardenolides / chemistry*
Cardenolides / isolation & purification
Cell Line, Tumor
Glycosides / analysis*
Glycosides / chemistry
HeLa Cells
Humans
Molecular Structure
Plant Roots / chemistry
|
| IF |
3.782
|
| Resource |
| Human and Animal Cells |
PANC-1(RCB2095)
HeLa(RCB0007) |
