Reference - Detail
| RRC ID | 6151 |
|---|---|
| Author | Chikayama E, Sekiyama Y, Okamoto M, Nakanishi Y, Tsuboi Y, Akiyama K, Saito K, Shinozaki K, Kikuchi J. |
| Title | Statistical indices for simultaneous large-scale metabolite detections for a single NMR spectrum. |
| Journal | Anal Chem |
| Abstract |
NMR-based metabolomics has become a practical and analytical methodology for discovering novel genes, biomarkers, metabolic phenotypes, and dynamic cell behaviors in organisms. Recent developments in NMR-based metabolomics, however, have not concentrated on improvements of comprehensiveness in terms of simultaneous large-scale metabolite detections. To resolve this, we have devised and implemented a statistical index, the SpinAssign p-value, in NMR-based metabolomics for large-scale metabolite annotation and publicized this information. It enables simultaneous annotation of more than 200 candidate metabolites from the single (13)C-HSQC (heteronuclear single quantum coherence) NMR spectrum of a single sample of cell extract. |
| Volume | 82(5) |
| Pages | 1653-8 |
| Published | 2010-3-1 |
| DOI | 10.1021/ac9022023 |
| PMID | 20128615 |
| MeSH | Metabolomics* Nuclear Magnetic Resonance, Biomolecular / methods* |
| IF | 6.785 |
| Times Cited | 89 |
| WOS Category | CHEMISTRY, ANALYTICAL |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Resource | |
| Arabidopsis / Cultured plant cells, genes | rpc00008 |