| RRC ID |
61543
|
| Author |
Namiki Y, Namiki T, Date M, Yanagihara K, Yashiro M, Takahashi H.
|
| Title |
Enhanced photodynamic antitumor effect on gastric cancer by a novel photosensitive stealth liposome.
|
| Journal |
Pharmacol Res
|
| Abstract |
Lipophilic photosensitizers hold potential for cancer photodynamic therapy. We sought to develop a novel photosensitive stealth liposome (PSSL) which incorporating a lipophilic photosensitizer into its lipid bilayer and to examine its photoactivity. We prepared PSSL composed of lipophilic chlorin e6 (Ce6) ester, dilauroylphosphatidylcholine, dioleoylphosphatidylethanolamine and distearoyl-phosphoethanolamine-N-[poly (ethylene glycol) 2000] and evaluated its photodynamic effect against gastric cancer cell lines and tumor-bearing nude mice models. In gastric cancer cell lines, LC(80) of PSSL was a maximum of 53 times as low as that of Ce6 sodium salt (Ce6-Na). PSSL completely destroyed all tumors in animal models and tumor recurrence levels were minimal (1.5 +/- 0.9%). PSSL achieved greater photodynamic effects in gastric cancer cell lines and in murine models than Ce6-Na. PSSL holds promise for photodynamic therapy for gastric cancer.
|
| Volume |
50(1)
|
| Pages |
65-76
|
| Published |
2004-7-1
|
| DOI |
10.1016/j.phrs.2003.12.015
|
| PII |
S1043661803004225
|
| PMID |
15082031
|
| MeSH |
Animals
Cell Line, Tumor
Drug Carriers
Lasers
Lipid Bilayers
Liposomes
Mice
Mice, Nude
Microscopy, Fluorescence
Neoplasm Transplantation
Photochemotherapy*
Photosensitizing Agents / administration & dosage*
Photosensitizing Agents / pharmacokinetics
Photosensitizing Agents / therapeutic use*
Spectrophotometry, Ultraviolet
Stomach Neoplasms / pathology
Stomach Neoplasms / therapy*
Tissue Distribution
|
| IF |
5.893
|
| Resource |
| Human and Animal Cells |
MKN45(RCB1001)
MKN74(RCB1002)
MKN7(RCB0999) |
