論文 - 詳細
| RRC ID | 61598 |
|---|---|
| 著者 | Hirata K, Takada M, Suzuki Y, Kuroda Y. |
| タイトル | Expression of receptor for advanced glycation end products (RAGE) in human biliary cancer cells. |
| ジャーナル | Hepatogastroenterology |
| Abstract |
BACKGROUND/AIMS:Amphoterin is considered as a regulator for the ability of invasion and migration in tumor cells and embryonic neurons through binding to RAGE (receptor for advanced glycation end products), a mult-iligand cell surface molecule of the immunoglobulin superfamily. METHODOLOGY:To see the involvement of RAGE in biliary cancer, three representative human biliary cancer cells (SK-ChA-1, TGBC-1 and NOZC-1) were rendered for the study. Cell invasion ability was determined using Matrigel invasion assay. The expression of RAGE protein was studied by Western blotting. RESULTS:Cell invasion assay through Matrigel showed high invasion potential in SK-ChA-1 and NOZC-1 (40.3 +/- 3.27, 48.7 +/- 4.8); low invasion potential in TGBC-1 (25.7 +/- 2.8). RAGE was strongly expressed in SK-ChA-1 and NOZC-1 that have high invasion ability. On the contrary, RAGE was faintly expressed in TGBC-1 that has low ability. CONCLUSIONS:RAGE is expressed in concordance to the invasion ability of the human biliary cancer cells. Control of this molecule could be a key to regulate the invasion ability of biliary cancers. |
| 巻・号 | 50(53) |
| ページ | 1205-7 |
| 公開日 | 2003-1-1 |
| PMID | 14571699 |
| MeSH | Bile Duct Neoplasms / metabolism* Bile Duct Neoplasms / pathology Biocompatible Materials Collagen Drug Combinations Gallbladder Neoplasms / metabolism* Gallbladder Neoplasms / pathology Glycation End Products, Advanced / metabolism* Humans Laminin Neoplasm Invasiveness Proteoglycans Receptor for Advanced Glycation End Products Receptors, Immunologic / metabolism* Tumor Cells, Cultured |
| リソース情報 | |
| ヒト・動物細胞 | TGBC1TKB(RCB1129) |