| RRC ID |
61609
|
| 著者 |
Nitta S, Komatsu A, Ishii T, Ohnishi M, Inoue A, Iwamoto H.
|
| タイトル |
Fabrication and characterization of water-dispersed chitosan nanofiber/poly(ethylene glycol) diacrylate/calcium phosphate-based porous composites.
|
| ジャーナル |
Carbohydr Polym
|
| Abstract |
We evaluated the capacity of chitosan nanofiber (CNF)- and poly(ethylene glycol) (PEG)-based hydrogel/calcium phosphate hybrid (CNF-PEG/CaP) composites to act as scaffolding materials. CNF-PEG/CaP composites were fabricated by mineralization of CNF-PEG hydrogels using an alternate soaking method. The amount of CaP mineralized on CNF-PEG hydrogels increased as the ratio of CNF in the CNF-PEG hydrogel increased. Young's modulus of CNF-PEG/CaP hydrogels was enhanced by increase in CNF ratio. It was further confirmed that osteoblasts embedded on the CNF-PEG/CaP composites were viable after incubation for 5days and firmly attached to the CaP porous layer, forming an extensive cell-scaffold leading to cell-cell interactions. These results indicated that the micro-porous structure of CNF-PEG hydrogels is suitable for CaP to be utilized as a scaffold for bone regeneration.
|
| 巻・号 |
174
|
| ページ |
1034-1040
|
| 公開日 |
2017-10-15
|
| DOI |
10.1016/j.carbpol.2017.06.111
|
| PII |
S0144-8617(17)30748-8
|
| PMID |
28821025
|
| IF |
7.182
|
| リソース情報 |
| ヒト・動物細胞 |
MC3T3-E1(RCB1126) |
