Reference - Detail
| RRC ID | 61719 |
|---|---|
| Author | Maeda R, Ida T, Ihara H, Sakamoto T. |
| Title | Induction of apoptosis in MCF-7 cells by β-1,3-xylooligosaccharides prepared from Caulerpa lentillifera. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
β-1,3-Xylan was prepared from the green alga, Caulerpa lentillifera, and hydrolyzed to oligosaccharides by a mild acid treatment. The average degree of polymerization was about 5. The oligosaccharides reduced the number of viable human breast cancer MCF-7 cells in a dose-dependent manner, and induced chromatin condensation and degradation of poly ADP-ribose polymerase, indicating that they induced apoptosis in MCF-7 cells. |
| Volume | 76(5) |
| Pages | 1032-4 |
| Published | 2012-1-1 |
| DOI | 10.1271/bbb.120016 |
| PII | DN/JST.JSTAGE/bbb/120016 |
| PMID | 22738982 |
| MeSH | Antineoplastic Agents, Phytogenic / isolation & purification Antineoplastic Agents, Phytogenic / pharmacology* Apoptosis / drug effects* Caulerpa / chemistry* Cell Line, Tumor Cell Proliferation / drug effects Cell Survival / drug effects Chromatin / drug effects Dose-Response Relationship, Drug Female Humans Oligosaccharides / isolation & purification Oligosaccharides / pharmacology* Plant Extracts / chemistry* Poly(ADP-ribose) Polymerase Inhibitors Protein Denaturation Sodium Hydroxide / chemistry Sulfuric Acids / chemistry Xylans / isolation & purification Xylans / pharmacology* |
| IF | 1.516 |
| Resource | |
| Human and Animal Cells | NB1RGB(RCB0222) |