論文 - 詳細
| RRC ID | 61803 |
|---|---|
| 著者 | Nakamura S, Moriura T, Park S, Fujimoto K, Matsumoto T, Ohta T, Matsuda H, Yoshikawa M. |
| タイトル | Melanogenesis inhibitory and fibroblast proliferation accelerating effects of noroleanane- and oleanane-type triterpene oligoglycosides from the flower buds of Camellia japonica. |
| ジャーナル | J Nat Prod |
| Abstract |
A 28-noroleanane-type triterpene oligoglycoside, camellioside E (4), an oleanane-type triterpene oligoglycoside, camellioside F (5), and the known compounds camelliosides A (1) and D (3) were isolated from a 50% EtOH extract of Camellia japonica flower buds from Korea. The principal constituents (1 and 5) significantly inhibited melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells. Camellioside B (2), a major constituent of C. japonica grown in Japan, showed potent inhibition of melanogenesis [95.0 ± 1.0% (p < 0.01) at 20 μM]. The inhibitory effects of 1, 2, and 5 were stronger than that of the reference compound, arbutin. We believe the melanogenesis inhibitory effects of 2 and 5 are partly related to the proliferation inhibitory effects in B16 melanoma 4A5 cells. Conversely, camelliosides tended to enhance proliferation in normal human neonatal skin fibroblasts. Interestingly, camellioside B (2) significantly accelerated fibroblast proliferation. This biological selectivity could make camellioside B useful for treating skin disorders. Herein, we report the first scientific investigation of a triterpene that displays an inhibitory effect on melanogenesis, but that also has an enhancing effect on fibroblast proliferation. |
| 巻・号 | 75(8) |
| ページ | 1425-30 |
| 公開日 | 2012-8-24 |
| DOI | 10.1021/np3001078 |
| PMID | 22834923 |
| MeSH | Animals Camellia / chemistry* Fibroblasts / drug effects* Flowers / drug effects Humans Melanins / biosynthesis Melanoma, Experimental / drug therapy* Mice Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oleanolic Acid / chemistry Oleanolic Acid / isolation & purification* Oleanolic Acid / pharmacology* Republic of Korea Saponins / chemistry Saponins / isolation & purification* Saponins / pharmacology* Skin / cytology |
| IF | 3.782 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 6.0 |
| リソース情報 | |
| ヒト・動物細胞 | B16 melanoma 4A5(RCB0557) |