| RRC ID |
61825
|
| 著者 |
Zhang Z, Hou C, Meng F, Zhao X, Zhang Z, Huang G, Chen W, Fu M, Liao W.
|
| タイトル |
MiR-455-3p regulates early chondrogenic differentiation via inhibiting Runx2.
|
| ジャーナル |
FEBS Lett
|
| Abstract |
The expression of miR-455-3p has been shown to be up-regulated in chondrogenesis of mesenchymal stem cell, but its role in different stages during chondrogenesis remains unknown. Here, we show that miR-455-3p is increased in ATDC5 cells from 0 d to 21 d, but rapidly decreases at 28 d, and a similar expression kinetic is detected in the development of mouse embryos. We show that miR-455-3p functions as an activator for early chondrogenic differentiation, most likely by inhibiting the expression of Runt-related transcription factor 2 (Runx2) as indicated by luciferase reporter assays. In conclusion, miR-455-3p may activate early chondrogenesis by directly targeting Runx2.
|
| 巻・号 |
589(23)
|
| ページ |
3671-8
|
| 公開日 |
2015-11-30
|
| DOI |
10.1016/j.febslet.2015.09.032
|
| PII |
S0014-5793(15)00887-X
|
| PMID |
26474644
|
| MeSH |
Animals
Cell Differentiation / genetics*
Cell Line
Chondrogenesis / genetics*
Core Binding Factor Alpha 1 Subunit / genetics*
Gene Expression Regulation, Developmental
Mice
MicroRNAs / genetics*
Time Factors
|
| IF |
3.057
|
| リソース情報 |
| ヒト・動物細胞 |
ATDC5(RCB0565) |
