論文 - 詳細
| RRC ID | 61825 |
|---|---|
| 著者 | Zhang Z, Hou C, Meng F, Zhao X, Zhang Z, Huang G, Chen W, Fu M, Liao W. |
| タイトル | MiR-455-3p regulates early chondrogenic differentiation via inhibiting Runx2. |
| ジャーナル | FEBS Lett |
| Abstract |
The expression of miR-455-3p has been shown to be up-regulated in chondrogenesis of mesenchymal stem cell, but its role in different stages during chondrogenesis remains unknown. Here, we show that miR-455-3p is increased in ATDC5 cells from 0 d to 21 d, but rapidly decreases at 28 d, and a similar expression kinetic is detected in the development of mouse embryos. We show that miR-455-3p functions as an activator for early chondrogenic differentiation, most likely by inhibiting the expression of Runt-related transcription factor 2 (Runx2) as indicated by luciferase reporter assays. In conclusion, miR-455-3p may activate early chondrogenesis by directly targeting Runx2. |
| 巻・号 | 589(23) |
| ページ | 3671-8 |
| 公開日 | 2015-11-30 |
| DOI | 10.1016/j.febslet.2015.09.032 |
| PII | S0014-5793(15)00887-X |
| PMID | 26474644 |
| MeSH | Animals Cell Differentiation / genetics* Cell Line Chondrogenesis / genetics* Core Binding Factor Alpha 1 Subunit / genetics* Gene Expression Regulation, Developmental Mice MicroRNAs / genetics* Time Factors |
| IF | 3.057 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | ATDC5(RCB0565) |