RRC ID 61864
著者 Wang XL, Xu KP, Long HP, Zou H, Cao XZ, Zhang K, Hu JZ, He SJ, Zhu GZ, He XA, Xu PS, Tan GS.
タイトル New isoindolinones from the fruiting bodies of Hericium erinaceum.
ジャーナル Fitoterapia
Abstract Hericium erinaceus is a well-known medicinal and edible mushroom, which is considered as a potential source to obtain antitumor candidates. In this work, five new isoindolinones, named erinaceolactams A-E (1-5), along with five known compounds (6-10), were isolated from 70% ethanol extract of the fruiting bodies of H. erinaceus. The structures of new compounds were validated by HRESIMS and 1D, 2D NMR. It's worth mentioning that there are two pairs of isomers included in the new compounds. Moreover, their cytotoxicity against metastatic human hepatocellular carcinoma cell lines SMMC-7221 and MHCC-97H were evaluated. The results showed that compounds 6 and 7 exhibited promising inhibitory potency against the growth of two cell lines.
巻・号 111
ページ 58-65
公開日 2016-6-1
DOI 10.1016/j.fitote.2016.04.010
PII S0367-326X(16)30084-3
PMID 27094113
MeSH Agaricales / chemistry Basidiomycota / chemistry* Cell Line, Tumor Fruiting Bodies, Fungal / chemistry Humans Indoles / chemistry Indoles / isolation & purification* Isoindoles / chemistry Isoindoles / isolation & purification Molecular Structure Phenols / chemistry Phenols / isolation & purification
IF 2.527
リソース情報
ヒト・動物細胞 OVK18(RCB1903)