| RRC ID |
61874
|
| 著者 |
Shinmi D, Nakano R, Mitamura K, Suzuki-Imaizumi M, Iwano J, Isoda Y, Enokizono J, Shiraishi Y, Arakawa E, Tomizuka K, Masuda K.
|
| タイトル |
Novel anticarcinoembryonic antigen antibody-drug conjugate has antitumor activity in the existence of soluble antigen.
|
| ジャーナル |
Cancer Med
|
| Abstract |
Carcinoembryonic antigen (CEA) is a classic tumor-specific antigen that is overexpressed in several cancers, including gastric cancer. Although some anti-CEA antibodies have been tested, to the best of our knowledge, there are currently no clinically approved anti-CEA antibody therapies. Because of this, we have created the novel anti-CEA antibody, 15-1-32, which exhibits stronger binding to membrane-bound CEA on cancer cells than existing anti-CEA antibodies. 15-1-32 also shows poor affinity for soluble CEA; thus, the binding activity of 15-1-32 to membrane-bound CEA is not influenced by soluble CEA. In addition, we constructed a 15-1-32-monomethyl auristatin E conjugate (15-1-32-vcMMAE) to improve the therapeutic efficacy of 15-1-32. 15-1-32-vcMMAE showed enhanced antitumor activity against gastric cancer cell lines. Unlike with existing anti-CEA antibody therapies, antitumor activity of 15-1-32-vcMMAE was retained in the presence of high concentrations of soluble CEA.
|
| 巻・号 |
6(4)
|
| ページ |
798-808
|
| 公開日 |
2017-4-1
|
| DOI |
10.1002/cam4.1003
|
| PMID |
28211613
|
| PMC |
PMC5387159
|
| MeSH |
Animals
Antibodies, Monoclonal / administration & dosage*
Antibodies, Monoclonal / chemistry
Antibodies, Monoclonal / pharmacology
Carcinoembryonic Antigen / immunology*
Cell Line, Tumor
Cell Proliferation / drug effects
Cell Survival / drug effects
Humans
Mice
Oligopeptides / chemistry*
Stomach Neoplasms / drug therapy*
|
| IF |
3.491
|
| リソース情報 |
| ヒト・動物細胞 |
L929 |
