論文 - 詳細
| RRC ID | 61882 |
|---|---|
| 著者 | Chakrabarti S, Visweswariah SS. |
| タイトル | Intramacrophage ROS Primes the Innate Immune System via JAK/STAT and Toll Activation. |
| ジャーナル | Cell Rep |
| Abstract |
Tissue injury is one of the most severe environmental perturbations for a living organism. When damage occurs in adult Drosophila, there is a local response of the injured tissue and a coordinated action across different tissues to help the organism overcome the deleterious effect of an injury. We show a change in the transcriptome of hemocytes at the site of tissue injury, with pronounced activation of the Toll signaling pathway. We find that induction of the cytokine upd-3 and Toll receptor activation occur in response to injury alone, in the absence of a pathogen. Intracellular accumulation of hydrogen peroxide in hemocytes is essential for upd-3 induction and is facilitated by the diffusion of hydrogen peroxide through a channel protein Prip. Importantly, hemocyte activation and production of reactive oxygen species (ROS) at the site of a sterile injury provide protection to flies on subsequent infection, demonstrating training of the innate immune system. |
| 巻・号 | 33(6) |
| ページ | 108368 |
| 公開日 | 2020-11-10 |
| DOI | 10.1016/j.celrep.2020.108368 |
| PII | S2211-1247(20)31357-7 |
| PMID | 33176146 |
| PMC | PMC7662148 |
| MeSH | Animals Drosophila / metabolism* Drosophila Proteins / metabolism* Immunity, Innate / physiology* Janus Kinases / metabolism* Macrophages / metabolism* Reactive Oxygen Species STAT Transcription Factors / metabolism* |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 47 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 5988R-3,7873R-3 |