論文 - 詳細
| RRC ID | 61932 |
|---|---|
| 著者 | Tsutsumi K, Kaname T, Shiraishi H, Kawashiri T, Egashira N. |
| タイトル | Polaprezinc reduces paclitaxel-induced peripheral neuropathy in rats without affecting anti-tumor activity. |
| ジャーナル | J Pharmacol Sci |
| Abstract |
Paclitaxel, an anticancer drug, frequently causes painful peripheral neuropathy. In this study, we investigated the preventive effect of polaprezinc on paclitaxel-induced peripheral neuropathy in rats. Polaprezinc (3 mg/kg, p.o., once daily) inhibited the development of mechanical allodynia induced by paclitaxel (4 mg/kg, i.p., on days 1, 3, 5 and 7) and suppressed the paclitaxel-induced increase in macrophage migration in dorsal root ganglion cells. In addition, polaprezinc did not affect the anti-tumor activity of paclitaxel in cultured cell lines or tumor-bearing mice. These results suggest a clinical indication for polaprezinc in the prevention of paclitaxel-induced neuropathy. |
| 巻・号 | 131(2) |
| ページ | 146-9 |
| 公開日 | 2016-6-1 |
| DOI | 10.1016/j.jphs.2016.04.019 |
| PII | S1347-8613(16)30036-6 |
| PMID | 27262900 |
| MeSH | Analgesics / therapeutic use* Animals Antineoplastic Agents, Phytogenic / adverse effects* Antineoplastic Agents, Phytogenic / therapeutic use Carnosine / analogs & derivatives* Carnosine / therapeutic use Cell Line, Tumor Cell Survival / drug effects Hyperalgesia / chemically induced Hyperalgesia / drug therapy* Male Mice Mice, Inbred C57BL Neoplasms / drug therapy Neoplasms / pathology Organometallic Compounds / therapeutic use* Paclitaxel / adverse effects* Paclitaxel / therapeutic use Peripheral Nervous System Diseases / chemically induced Peripheral Nervous System Diseases / drug therapy* Rats Rats, Sprague-Dawley Tumor Burden / drug effects Zinc Compounds / therapeutic use |
| IF | 2.835 |
| リソース情報 | |
| ヒト・動物細胞 | LLC(RCB0558) |