| RRC ID |
62000
|
| Author |
Nakano T, Okaie Y, Kinugasa Y, Koujin T, Suda T, Hiraoka Y, Haraguchi T.
|
| Title |
Roles of Remote and Contact Forces in Epithelial Cell Structure Formation.
|
| Journal |
Biophys J
|
| Abstract |
Cancer cells collectively form a large-scale structure for their growth. In this article, we report that HeLa cells, epithelial-like human cervical cancer cells, aggressively migrate on Matrigel and form a large-scale structure in a cell-density-dependent manner. To explain the experimental results, we develop a simple model in which cells interact and migrate using the two fundamentally different types of force, remote and contact forces, and show how cells form a large-scale structure. We demonstrate that the simple model reproduces experimental observations, suggesting that the remote and contact forces considered in this work play a major role in large-scale structure formation of HeLa cells. This article provides important evidence that cancer cells form a large-scale structure and develops an understanding into the poorly understood mechanisms of their structure formation.
|
| Volume |
118(6)
|
| Pages |
1466-1478
|
| Published |
2020-3-24
|
| DOI |
10.1016/j.bpj.2020.01.037
|
| PII |
S0006-3495(20)30112-0
|
| PMID |
32097624
|
| PMC |
PMC7091513
|
| MeSH |
Cell Count
Epithelial Cells*
HeLa Cells
Humans
|
| IF |
3.854
|
| Resource |
| Human and Animal Cells |
HeLa |
