Reference - Detail
| RRC ID | 62014 |
|---|---|
| Author | Woo E, Park H, Lee KY. |
| Title | Shear reversible cell/microsphere aggregate as an injectable for tissue regeneration. |
| Journal | Macromol Biosci |
| Abstract |
Injectable delivery systems have been widely used in tissue engineering as they can deliver cells into the body in a minimally invasive manner. In this study, it is hypothesized that microspheres with a similar size of cells could effectively form a shear reversible aggregate in the presence of cells and the aggregate could be useful to engineer tissues. Alginate microspheres are prepared by an emulsion method, followed by modification with a peptide containing the arginine-glycine-aspartic acid (RGD) sequence. RGD-modified alginate microspheres form an aggregate in the presence of chondrocytes, and the aggregation behavior is shear reversible. This cell/microsphere aggregate is useful to deliver chondrocytes into an animal model using a syringe, and effectively regenerates cartilage tissues in vivo. |
| Volume | 14(5) |
| Pages | 740-8 |
| Published | 2014-5-1 |
| DOI | 10.1002/mabi.201300365 |
| PMID | 24436180 |
| MeSH | Alginates / chemistry Animals Cartilage / physiology Chondrocytes / metabolism* DNA Primers / genetics Drug Delivery Systems / methods* Glycosaminoglycans / analysis Guided Tissue Regeneration / methods* Mice Mice, Inbred BALB C Microspheres* Oligopeptides / chemistry Rabbits Reverse Transcriptase Polymerase Chain Reaction Rheology Shear Strength Tissue Engineering / methods* |
| IF | 3.416 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | ATDC5(RCB0565) |