Reference - Detail
| RRC ID | 62040 |
|---|---|
| Author | Yamada A, Kawano K, Harashima N, Niiya F, Nagai K, Kobayashi T, Mine T, Ushijima K, Nishida T, Itoh K. |
| Title | Study of HLA class I restriction and the directed antigens of cytotoxic T lymphocytes at the tumor sites of ovarian cancer. |
| Journal | Cancer Immunol Immunother |
| Abstract |
The molecular basis of T-cell-mediated recognition of ovarian cancer cells remains to be fully addressed. In this study we investigated HLA class I restriction and directed antigens of cytotoxic T lymphocytes (CTL) at the sites of ovarian cancer. Three HLA-class-I-restricted CTL lines were established from the tumor sites of ovarian cancer by culturing tumor-infiltrating lymphocytes or tumor-associated ascitic lymphocytes with interleukin-2: (1) HLA-A2402-restricted and ovarian-adenocarcinoma-specific CTL, (2) HLA-A2-restricted CTL recognizing histologically different cancers, and (3) HLA-B52-restricted and ovarian-cancer-specific CTL. HLA-A0201, HLA-A0206 and HLA-A0207 tumor cells were lysed by the HLA-A2-restricted CTL. HLA-B52 restriction of the third CTL line was confirmed by the transfection of HLA-B5201 cDNA into the tumor cells. The HLA-A2-restricted CTL recognized the SART-1, but not the MAGE-1 or MAGE-3 antigen. These results may facilitate a better understanding of the molecular basis of tumor-specific immunity at the tumor site of ovarian cancer. |
| Volume | 48(2-3) |
| Pages | 147-52 |
| Published | 1999-1-1 |
| DOI | 10.1007/s002620050559 |
| PMID | 10414469 |
| MeSH | Animals Antigens, Neoplasm / immunology* COS Cells Female Histocompatibility Antigens Class I / physiology* Humans Interferon-gamma / biosynthesis Melanoma-Specific Antigens Neoplasm Proteins / immunology Ovarian Neoplasms / immunology* Ribonucleoproteins, Small Nuclear* T-Lymphocytes, Cytotoxic / immunology* Tumor Cells, Cultured |
| IF | 5.442 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 7 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | OMC-3(RCB0755) HTOA(RCB0692) |