論文 - 詳細
| RRC ID | 62193 |
|---|---|
| 著者 | Farghaly TA, Abdalla MM. |
| タイトル | Synthesis, tautomerism, and antimicrobial, anti-HCV, anti-SSPE, antioxidant, and antitumor activities of arylazobenzosuberones. |
| ジャーナル | Bioorg Med Chem |
| Abstract |
2-Dimethylaminomethylene-1-benzosuberone 1 was coupled with diazotized aniline derivatives to afford a series of the hitherto unreported 2-arylazo-1-benzosuberones 3a-i. The tautomeric structure and the effect of substituents on the tautomeric form (s) of the products 3a-i were discussed. Similar coupling of the enaminone 1 with diazonium salts of heterocyclic amines gave the respective fused azolotriazino-benzosuberones. Some of the newly synthesized compounds showed potent antimicrobial, anti-HCV, antioxidant, antitumor (as topoisomerase I inhibitors), and antimicrobial activities. |
| 巻・号 | 17(23) |
| ページ | 8012-9 |
| 公開日 | 2009-12-1 |
| DOI | 10.1016/j.bmc.2009.10.012 |
| PII | S0968-0896(09)00931-6 |
| PMID | 19864149 |
| MeSH | Animals Anti-Bacterial Agents / chemical synthesis* Anti-Bacterial Agents / chemistry Anti-Bacterial Agents / pharmacology Antineoplastic Agents / chemical synthesis* Antineoplastic Agents / chemistry Antineoplastic Agents / pharmacology Antioxidants / chemical synthesis* Antioxidants / chemistry Antioxidants / pharmacology Antiviral Agents / chemical synthesis* Antiviral Agents / chemistry Antiviral Agents / pharmacology Azo Compounds / chemical synthesis* Azo Compounds / chemistry Azo Compounds / pharmacology Biphenyl Compounds / metabolism Cricetinae Hepacivirus / growth & development Hydrazones / chemical synthesis* Hydrazones / chemistry Hydrazones / pharmacology Inhibitory Concentration 50 Magnetic Resonance Spectroscopy Mass Spectrometry Mice Microbial Sensitivity Tests Neoplasms, Experimental / drug therapy Picrates / metabolism SSPE Virus / growth & development Spectrophotometry, Infrared |
| IF | 3.073 |
| リソース情報 | |
| ヒト・動物細胞 | HGC-27(RCB0500) |