論文 - 詳細
| RRC ID | 62194 |
|---|---|
| 著者 | Parameswaran S, Balasubramanian S, Babai N, Qiu F, Eudy JD, Thoreson WB, Ahmad I. |
| タイトル | Induced pluripotent stem cells generate both retinal ganglion cells and photoreceptors: therapeutic implications in degenerative changes in glaucoma and age-related macular degeneration. |
| ジャーナル | Stem Cells |
| Abstract |
The direct reprogramming of somatic cells to a pluripotent state holds significant implications for treating intractable degenerative diseases by ex vivo cell therapy. In addition, the reprogrammed cells can serve as a model for diseases and the discovery of drugs and genes. Here, we demonstrate that mouse fibroblast induced pluripotent stem cells (iPSCs) represent a renewable and robust source of retinal progenitors, capable of generating a wide range of retinal cell types that includes retinal ganglion cells (RGCs), cone, and rod photoreceptors. They respond to simulated microenvironment of early and late retinal histogenesis by differentiating into stage-specific retinal cell types through the recruitment of normal mechanisms. The depth of the retinal potential of iPSCs suggests that they may be used to formulate stem cell approaches to understand and treat a wide range of retinal degenerative diseases from glaucoma to age-related macular degeneration (AMD). |
| 巻・号 | 28(4) |
| ページ | 695-703 |
| 公開日 | 2010-4-1 |
| DOI | 10.1002/stem.320 |
| PMID | 20166150 |
| MeSH | Animals Cell Differentiation* Cell Line Cell Lineage Gene Expression Regulation Glaucoma / therapy* Induced Pluripotent Stem Cells / cytology* Induced Pluripotent Stem Cells / metabolism Macular Degeneration / therapy* Mice Photoreceptor Cells / cytology* Photoreceptor Cells / metabolism Retinal Ganglion Cells / cytology* Retinal Ganglion Cells / metabolism |
| IF | 6.022 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 17 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| ヒト・動物細胞 | iPS-MEF-Ng-20D-17(APS0001) |