Reference - Detail
| RRC ID | 62198 |
|---|---|
| Author | Simon CG Jr, Yang Y, Dorsey SM, Ramalingam M, Chatterjee K. |
| Title | 3D polymer scaffold arrays. |
| Journal | Methods Mol Biol |
| Abstract |
We have developed a combinatorial platform for fabricating tissue scaffold arrays that can be used for screening cell-material interactions. Traditional research involves preparing samples one at a time for characterization and testing. Combinatorial and high-throughput (CHT) methods lower the cost of research by reducing the amount of time and material required for experiments by combining many samples into miniaturized specimens. In order to help accelerate biomaterials research, many new CHT methods have been developed for screening cell-material interactions where materials are presented to cells as a 2D film or surface. However, biomaterials are frequently used to fabricate 3D scaffolds, cells exist in vivo in a 3D environment and cells cultured in a 3D environment in vitro typically behave more physiologically than those cultured on a 2D surface. Thus, we have developed a platform for fabricating tissue scaffold libraries where biomaterials can be presented to cells in a 3D format. |
| Volume | 671 |
| Pages | 161-74 |
| Published | 2011-1-1 |
| DOI | 10.1007/978-1-59745-551-0_9 |
| PMID | 20967629 |
| MeSH | Animals Cell Adhesion Cell Culture Techniques / instrumentation* Cell Line Cell Proliferation Combinatorial Chemistry Techniques / economics Combinatorial Chemistry Techniques / methods* Equipment Design Humans Microscopy, Electron, Scanning Polymers / chemistry* Porosity Tissue Scaffolds / chemistry* |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | MC3T3-E1(RCB1126) |