RRC ID 62206
Author Choi EM.
Title Honokiol isolated from Magnolia officinalis stimulates osteoblast function and inhibits the release of bone-resorbing mediators.
Journal Int Immunopharmacol
Abstract There has been a strong interest in searching for natural therapies for osteoporosis. Honokiol is a phenolic compound isolated from the bark of Magnolia officinalis, a plant widely used in traditional medicine. In the present study, the effects of honokiol on the function of osteoblastic MC3T3-E1 cells were studied. Honokiol caused a significant elevation of cell growth, alkaline phosphatase activity, collagen synthesis, mineralization, glutathione content, and osteoprotegerin release in the cells (P<0.05). Moreover, honokiol significantly (P<0.05) decreased the production of osteoclast differentiation inducing factors such as TNF-α, IL-6, and receptor activator of nuclear factor-kB ligand (RANKL) in the presence of antimycin A, which inhibits mitochondrial electron transport and has been used as a ROS generator. These results demonstrate that honokiol may have positive effects on skeletal structure.
Volume 11(10)
Pages 1541-5
Published 2011-10-1
DOI 10.1016/j.intimp.2011.05.011
PII S1567-5769(11)00222-0
PMID 21621646
MeSH Alkaline Phosphatase / metabolism Animals Antimycin A / analogs & derivatives Antimycin A / pharmacology Biphenyl Compounds / pharmacology* Biphenyl Compounds / therapeutic use Bone Resorption / prevention & control Calcification, Physiologic / drug effects Cell Growth Processes / drug effects Cell Line Collagen / genetics Collagen / metabolism Glutathione / metabolism Humans Interleukin-6 / genetics Interleukin-6 / metabolism Lignans / pharmacology* Lignans / therapeutic use Magnolia* Mice Osteoblasts / drug effects* Osteoblasts / metabolism Osteoblasts / pathology Osteoporosis / drug therapy* Osteoporosis / pathology Osteoporosis / physiopathology Osteoprotegerin / metabolism Phytotherapy* RANK Ligand / genetics RANK Ligand / metabolism Tumor Necrosis Factor-alpha / genetics Tumor Necrosis Factor-alpha / metabolism
IF 3.943
Human and Animal Cells MC3T3-E1(RCB1126)