論文 - 詳細
| RRC ID | 62707 |
|---|---|
| 著者 | Takeda Y, Murata T, Jamsransuren D, Suganuma K, Kazami Y, Batkhuu J, Badral D, Ogawa H. |
| タイトル | Saxifraga spinulosa-Derived Components Rapidly Inactivate Multiple Viruses Including SARS-CoV-2. |
| ジャーナル | Viruses |
| Abstract |
Novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A virus (IAV), and norovirus (NV) are highly contagious pathogens that threaten human health. Here we focused on the antiviral potential of the medicinal herb, Saxifraga spinulosa (SS). Water-soluble extracts of SS were prepared, and their virus-inactivating activity was evaluated against the human virus pathogens SARS-CoV-2 and IAV; we also examined virucidal activity against feline calicivirus and murine norovirus, which are surrogates for human NV. Among our findings, we found that SS-derived gallocatechin gallate compounds were capable of inactivating all viruses tested. Interestingly, a pyrogallol-enriched fraction (Fr 1C) inactivated all viruses more rapidly and effectively than did any of the component compounds used alone. We found that 25 µg/mL of Fr 1C inactivated >99.6% of SARS-CoV-2 within 10 s (reduction of ≥2.33 log10 TCID50/mL). Fr 1C resulted in the disruption of viral genomes and proteins as determined by gel electrophoresis, electron microscopy, and reverse transcription-PCR. Taken together, our results reveal the potential of Fr 1C for development as a novel antiviral disinfectant. |
| 巻・号 | 12(7) |
| 公開日 | 2020-6-28 |
| DOI | 10.3390/v12070699 |
| PII | v12070699 |
| PMID | 32605306 |
| PMC | PMC7411974 |
| MeSH | Antiviral Agents / pharmacology* Betacoronavirus / drug effects* Betacoronavirus / ultrastructure Calicivirus, Feline / drug effects Electrophoresis, Polyacrylamide Gel Genome, Viral / drug effects Hemagglutination Tests Humans Influenza A virus / drug effects* Microscopy, Electron, Transmission Norovirus / drug effects* Plant Extracts / pharmacology* Plants, Medicinal* Reverse Transcriptase Polymerase Chain Reaction SARS-CoV-2 Saxifragaceae* Viral Proteins / drug effects |
| IF | 3.816 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |