論文 - 詳細
| RRC ID | 62818 |
|---|---|
| 著者 | Matsumoto Y, Hattori K, Arima H, Motoyama K, Higashi T, Ishikawa H, Fukumitsu N, Aihara T, Nakai K, Kumada H, Sakurai H. |
| タイトル | Folate-appended cyclodextrin improves the intratumoral accumulation of existing boron compounds. |
| ジャーナル | Appl Radiat Isot |
| Abstract |
In this study, the tumor accumulation and antitumor effect of folate-modified cyclodextrin (ND201) purified with folate receptor (FR) connotated with BSH were examined. ND201 and BSH were stably bound in blood, and the mixing ratio 1:1 was most efficient. ND-BSH showed higher boron concentration (38.5 ppm) than BSH alone (11.25 ppm). The maximum ND-BSH tumor/blood ratio was also markedly higher (6.58) than that of BSH alone (1.04). ND-BSH showed a significant antitumor effect compared with BSH after neutron irradiation. |
| 巻・号 | 163 |
| ページ | 109201 |
| 公開日 | 2020-9-1 |
| DOI | 10.1016/j.apradiso.2020.109201 |
| PII | S0969-8043(20)30330-4 |
| PMID | 32561042 |
| MeSH | Animals Boron Compounds / blood Boron Compounds / metabolism* Boron Neutron Capture Therapy / methods Cell Line, Tumor Cyclodextrins / chemistry* Folic Acid / chemistry* Humans Mice Mice, Inbred BALB C Neoplasms / metabolism* Neoplasms / radiotherapy |
| IF | 1.27 |
| リソース情報 | |
| ヒト・動物細胞 | A549(RCB0098) |