RRC ID 62877
著者 Yoshizawa K, Tabuchi M, Ukai S, Suzuki H, Kawano Y, Takasawa R.
タイトル The Putative Glyoxalase 1 Inhibitor Piceatannol Exhibits Both Anxiolytic-like and Antitumor Effects in Mice.
ジャーナル Anticancer Res
Abstract BACKGROUND/AIM:This study aimed to determine the anxiolytic effect of a putative glyoxalase 1 inhibitor, piceatannol, as well as its antitumor activities on the stress-induced tumor growth of Lewis lung carcinoma.
MATERIALS AND METHODS:The anxiolytic activities of piceatannol (1-30 mg/kg) were assessed using the elevated plus maze (EPM) test. We also evaluated the pharmacological modulation of stress-induced tumor growth; the mice were treated with piceatannol (3 and 30 mg/kg) from the 10th day till the 19th day after administration of the LLC cells.
RESULTS:At the low dose (3 mg/kg), piceatannol significantly increased the time spent in the open arms of the EPM test when compared with the vehicle. At higher doses (30 mg/kg), it significantly suppressed the stress-induced enhancement of tumor growth.
CONCLUSION:A low dose of piceatannol exerts an anxiolytic effect, and high doses have an antitumor effect.
巻・号 40(6)
ページ 3271-3276
公開日 2020-6-1
DOI 10.21873/anticanres.14309
PII 40/6/3271
PMID 32487622
MeSH Animals Anti-Anxiety Agents / pharmacology Anti-Anxiety Agents / therapeutic use* Antineoplastic Agents / pharmacology Antineoplastic Agents / therapeutic use* Lactoylglutathione Lyase / antagonists & inhibitors* Lactoylglutathione Lyase / therapeutic use Male Mice Protein-Tyrosine Kinases / pharmacology Protein-Tyrosine Kinases / therapeutic use* Stilbenes / pharmacology Stilbenes / therapeutic use*
IF 1.994
リソース情報
ヒト・動物細胞 LLC(RCB0558)