論文 - 詳細
RRC ID | 62877 |
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著者 | Yoshizawa K, Tabuchi M, Ukai S, Suzuki H, Kawano Y, Takasawa R. |
タイトル | The Putative Glyoxalase 1 Inhibitor Piceatannol Exhibits Both Anxiolytic-like and Antitumor Effects in Mice. |
ジャーナル | Anticancer Res |
Abstract |
BACKGROUND/AIM:This study aimed to determine the anxiolytic effect of a putative glyoxalase 1 inhibitor, piceatannol, as well as its antitumor activities on the stress-induced tumor growth of Lewis lung carcinoma. MATERIALS AND METHODS:The anxiolytic activities of piceatannol (1-30 mg/kg) were assessed using the elevated plus maze (EPM) test. We also evaluated the pharmacological modulation of stress-induced tumor growth; the mice were treated with piceatannol (3 and 30 mg/kg) from the 10th day till the 19th day after administration of the LLC cells. RESULTS:At the low dose (3 mg/kg), piceatannol significantly increased the time spent in the open arms of the EPM test when compared with the vehicle. At higher doses (30 mg/kg), it significantly suppressed the stress-induced enhancement of tumor growth. CONCLUSION:A low dose of piceatannol exerts an anxiolytic effect, and high doses have an antitumor effect. |
巻・号 | 40(6) |
ページ | 3271-3276 |
公開日 | 2020-6-1 |
DOI | 10.21873/anticanres.14309 |
PII | 40/6/3271 |
PMID | 32487622 |
MeSH | Animals Anti-Anxiety Agents / pharmacology Anti-Anxiety Agents / therapeutic use* Antineoplastic Agents / pharmacology Antineoplastic Agents / therapeutic use* Lactoylglutathione Lyase / antagonists & inhibitors* Lactoylglutathione Lyase / therapeutic use Male Mice Protein-Tyrosine Kinases / pharmacology Protein-Tyrosine Kinases / therapeutic use* Stilbenes / pharmacology Stilbenes / therapeutic use* |
IF | 1.994 |
リソース情報 | |
ヒト・動物細胞 | LLC(RCB0558) |