RRC ID 62917
Author Uchiyama H, Dowaki M, Kadota K, Arima H, Sugiyama K, Tozuka Y.
Title Single-stranded β-1,3-1,6-glucan as a carrier for improved dissolution and membrane permeation of poorly water-soluble compounds.
Journal Carbohydr Polym
Abstract The ability of a water-soluble, single-stranded β-1,3/1,6-glucan (ssβ-glucan), recovered by hydrothermal treatment, to enhance the solubility and membrane permeability of poorly water-soluble compounds was examined. As a poorly water-soluble model compound, quercetin (QUE) was used. The aqueous solubility of spray-dried particles (SDPs) of QUE/ssβ-glucan was significantly enhanced compared with that of the untreated QUE powder and the physical mixture of QUE/ssβ-glucan. Fourier-transform infrared spectra and small-angle X-ray scattering suggested strong interactions between ssβ-glucan and QUE in the SDPs, which was attributable to QUE entrapment in the helical ssβ-glucan structure. The amount of QUE infused into Caco-2 cells from QUE/ssβ-glucan SDPs was 16-fold and 5-fold higher than the amount infused from untreated QUE powder and the physical mixture of QUE/ssβ-glucan, respectively. These results showed that water-soluble ssβ-glucan improved QUE dissolution and membrane permeability.
Volume 247
Pages 116698
Published 2020-11-1
DOI 10.1016/j.carbpol.2020.116698
PII S0144-8617(20)30872-9
PMID 32829826
MeSH Antioxidants / chemistry Antioxidants / pharmacology Caco-2 Cells Cell Membrane Permeability* Cell Survival / drug effects Drug Carriers / chemistry* Drug Liberation Humans Microscopy, Electron, Scanning Powder Diffraction Powders / analysis Powders / chemistry Quercetin / chemistry Quercetin / pharmacology Scattering, Small Angle Solubility* Spectroscopy, Fourier Transform Infrared Spray Drying Water / chemistry X-Ray Diffraction beta-Glucans / chemistry*
IF 7.182
Human and Animal Cells CACO-2(RCB0988)