| RRC ID |
62917
|
| 著者 |
Uchiyama H, Dowaki M, Kadota K, Arima H, Sugiyama K, Tozuka Y.
|
| タイトル |
Single-stranded β-1,3-1,6-glucan as a carrier for improved dissolution and membrane permeation of poorly water-soluble compounds.
|
| ジャーナル |
Carbohydr Polym
|
| Abstract |
The ability of a water-soluble, single-stranded β-1,3/1,6-glucan (ssβ-glucan), recovered by hydrothermal treatment, to enhance the solubility and membrane permeability of poorly water-soluble compounds was examined. As a poorly water-soluble model compound, quercetin (QUE) was used. The aqueous solubility of spray-dried particles (SDPs) of QUE/ssβ-glucan was significantly enhanced compared with that of the untreated QUE powder and the physical mixture of QUE/ssβ-glucan. Fourier-transform infrared spectra and small-angle X-ray scattering suggested strong interactions between ssβ-glucan and QUE in the SDPs, which was attributable to QUE entrapment in the helical ssβ-glucan structure. The amount of QUE infused into Caco-2 cells from QUE/ssβ-glucan SDPs was 16-fold and 5-fold higher than the amount infused from untreated QUE powder and the physical mixture of QUE/ssβ-glucan, respectively. These results showed that water-soluble ssβ-glucan improved QUE dissolution and membrane permeability.
|
| 巻・号 |
247
|
| ページ |
116698
|
| 公開日 |
2020-11-1
|
| DOI |
10.1016/j.carbpol.2020.116698
|
| PII |
S0144-8617(20)30872-9
|
| PMID |
32829826
|
| MeSH |
Antioxidants / chemistry
Antioxidants / pharmacology
Caco-2 Cells
Cell Membrane Permeability*
Cell Survival / drug effects
Drug Carriers / chemistry*
Drug Liberation
Humans
Microscopy, Electron, Scanning
Powder Diffraction
Powders / analysis
Powders / chemistry
Quercetin / chemistry
Quercetin / pharmacology
Scattering, Small Angle
Solubility*
Spectroscopy, Fourier Transform Infrared
Spray Drying
Water / chemistry
X-Ray Diffraction
beta-Glucans / chemistry*
|
| IF |
7.182
|
| リソース情報 |
| ヒト・動物細胞 |
CACO-2(RCB0988) |
