| RRC ID |
62953
|
| 著者 |
Liu W, Takahashi Y, Morishita M, Nishikawa M, Takakura Y.
|
| タイトル |
Development of CD40L-modified tumor small extracellular vesicles for effective induction of antitumor immune response.
|
| ジャーナル |
Nanomedicine (Lond)
|
| Abstract |
Aim: Tumor-derived small extracellular vesicles (TEVs) are considered for use in inducing tumor antigen-specific immune responses as they contain tumor antigens. The delivery of tumor antigens to the antigen presentation cells (especially dendritic cells [DCs]), and the activation of DCs are the main challenges of TEV therapy. Materials & methods: TEVs were modified with CD40 ligand (CD40L), which can target CD40 expressed on the surface of DCs and can activate them via CD40L-CD40 interactions. Results: It was found that CD40L-TEVs were efficiently taken up by DCs and also activated them. Moreover, tumor antigens were efficiently presented to the T cells by DCs treated with CD40L-TEVs. Conclusion: This study proved that CD40L-modification of TEVs will be helpful for further development of TEV-based tumor vaccination.
|
| 巻・号 |
15(17)
|
| ページ |
1641-1652
|
| 公開日 |
2020-7-1
|
| DOI |
10.2217/nnm-2020-0071
|
| PMID |
32664826
|
| MeSH |
CD40 Ligand*
Dendritic Cells
Extracellular Vesicles*
Humans
Immunity
Neoplasms* / therapy
|
| IF |
4.3
|
| リソース情報 |
| ヒト・動物細胞 |
B16/BL6(RCB2638) |
