論文 - 詳細
| RRC ID | 62965 |
|---|---|
| 著者 | Isayama T, Etoh H, Kishimoto N, Takasaki T, Kuratani A, Ikuta T, Tatefuji T, Takamune N, Muneoka A, Takahashi Y, Misumi S. |
| タイトル | 10-Hydroxydecanoic Acid Potentially Elicits Antigen-Specific IgA Responses. |
| ジャーナル | Biol Pharm Bull |
| Abstract |
The effective antigen (Ag) uptake by microfold cells (M-cells) is important for the induction of an efficient mucosal immune responses. Here, we show that 10-hydroxydecanoic acid (10-HDAA) from royal jelly (RJ) potentially supports M-cell differentiation and induces effective antigen-specific mucosal immune responses in cynomolgus macaques. 10-HDAA increases the expression level of receptor activator of nuclear factor-kappaB (NF-κB) (RANK) in Caco-2 cells, which suggests that 10-HDAA potentially prompts the differentiation of Caco-2 cells into M-cells and increased transcytosis efficiency. This idea is supported by the following observations. Intranasal administration of 10-HDAA increased the number of M-cells in the epithelium overlying nasopharynx-associated lymphoid tissue (NALT) in macaques. Oral administration of 10-HDAA increased the number of M-cells in the follicle-associated epithelium (FAE) covering Peyer's patches (PPs) and significantly increased the antigen-specific immunoglobulin A (IgA) level in macaques. These findings suggest that the exogenous honeybee-derived medium-chain fatty acid 10-HDAA may effectively enhance antigen-specific immune responses. |
| 巻・号 | 43(8) |
| ページ | 1202-1209 |
| 公開日 | 2020-1-1 |
| DOI | 10.1248/bpb.b20-00101 |
| PMID | 32741940 |
| MeSH | Animals Antigens / immunology Caco-2 Cells Cell Differentiation Decanoic Acids / pharmacology* Epithelial Cells / drug effects Epithelial Cells / immunology Humans Immunity, Mucosal / drug effects* Immunoglobulin A / biosynthesis* Intestinal Mucosa / immunology Macaca fascicularis Male RANK Ligand / genetics |
| IF | 1.863 |
| リソース情報 | |
| ヒト・動物細胞 | CACO-2(RCB0988) RAJI(RCB1647) |