論文 - 詳細
| RRC ID | 63194 |
|---|---|
| 著者 | Marques-Almeida T, Cardoso VF, Gama M, Lanceros-Mendez S, Ribeiro C. |
| タイトル | Patterned Piezoelectric Scaffolds for Osteogenic Differentiation. |
| ジャーナル | Int J Mol Sci |
| Abstract |
The morphological clues of scaffolds can determine cell behavior and, therefore, the patterning of electroactive polymers can be a suitable strategy for bone tissue engineering. In this way, this work reports on the influence of poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) electroactive micropatterned scaffolds on the proliferation and differentiation of bone cells. For that, micropatterned P(VDF-TrFE) scaffolds were produced by lithography in the form of arrays of lines and hexagons and then tested for cell proliferation and differentiation of pre-osteoblast cell line. Results show that more anisotropic surface microstructures promote bone differentiation without the need of further biochemical stimulation. Thus, the combination of specific patterns with the inherent electroactivity of materials provides a promising platform for bone regeneration. |
| 巻・号 | 21(21) |
| 公開日 | 2020-11-7 |
| DOI | 10.3390/ijms21218352 |
| PII | ijms21218352 |
| PMID | 33171761 |
| PMC | PMC7672637 |
| MeSH | 3T3 Cells Animals Biocompatible Materials / chemistry Bone Regeneration / drug effects* Bone and Bones / metabolism Cell Culture Techniques / methods Cell Differentiation / drug effects* Cell Proliferation Cell Survival Hydrocarbons, Fluorinated / chemistry* Hydrocarbons, Fluorinated / pharmacology Mice Osteoblasts / metabolism Osteogenesis Polyvinyls / chemistry Tissue Engineering / methods* Tissue Scaffolds / chemistry Titanium / chemistry Vinyl Compounds / chemistry* Vinyl Compounds / pharmacology |
| IF | 4.556 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |