| RRC ID |
63197
|
| 著者 |
Park E, Kim J, Jin HS, Choi CW, Choi TH, Choi S, Huh D, Jeong SY.
|
| タイトル |
Scopolin Attenuates Osteoporotic Bone Loss in Ovariectomized Mice.
|
| ジャーナル |
Nutrients
|
| Abstract |
Bone remodeling is a renewal process regulated by bone synthesis (osteoblasts) and bone destruction (osteoclasts). A previous study demonstrated that Lycii radicis cortex (LRC) extract inhibited ovariectomized (OVX)-induced bone loss in mice. This study investigated the anti-osteoporotic effects of bioactive constituent(s) from the LRC extract. The effective compound(s) were screened, and a single compound, scopolin, which acts as a phytoalexin, was chosen as a candidate component. Scopolin treatment enhanced alkaline phosphatase activity and increased mineralized nodule formation in MC3T3-E1 pre-osteoblastic cells. However, osteoclast differentiation in primary-cultured monocytes was reduced by treatment with scopolin. Consistently, scopolin treatment increased osteoblast differentiation in the co-culture of monocytes (osteoclasts) and MC3T3-E1 (osteoblast) cells. Scopolin treatment prevented bone mineral density loss in OVX-induced osteoporotic mice. These results suggest that scopolin could be a therapeutic bioactive constituent for the treatment and prevention of osteoporosis.
|
| 巻・号 |
12(11)
|
| 公開日 |
2020-11-20
|
| DOI |
10.3390/nu12113565
|
| PII |
nu12113565
|
| PMID |
33233714
|
| PMC |
PMC7699886
|
| MeSH |
3T3 Cells
Animals
Bone Density / drug effects
Cell Differentiation
Coumarins / pharmacology
Coumarins / therapeutic use*
Disease Models, Animal
Drugs, Chinese Herbal / pharmacology
Drugs, Chinese Herbal / therapeutic use*
Female
Glucosides / pharmacology
Glucosides / therapeutic use*
Mice
Osteoblasts / drug effects
Osteoclasts / drug effects
Osteogenesis / drug effects*
Osteoporosis / drug therapy*
Osteoporosis / prevention & control*
|
| IF |
4.546
|
| リソース情報 |
| ヒト・動物細胞 |
MC3T3-E1(RCB1126) |
