RRC ID 63200
Author Luo F, Sugita H, Muraki K, Saeki S, Chaipech S, Pongpiriyadacha Y, Muraoka O, Morikawa T.
Title Anti-proliferative activities of coumarins from the Thai medicinal plant Mammea siamensis (Miq.) T. Anders. against human digestive tract carcinoma cell lines.
Journal Fitoterapia
Abstract Geranylated coumarins named mammeasins G-J (1-4) were isolated from the methanol extract of the flowers of Mammea siamensis (Miq.) T. Anders. (Calophyllaceae) originating in Thailand. Their structures were established based on detailed spectroscopic analyses. The isolates, including previously reported coumarin constituents (5-28), exhibited anti-proliferative activities against human carcinoma cell lines HSC-2, HSC-4, MKN-45, and MCF-7. Mammeasin A (7, IC50 = 13.6 μM) and surangin B (15, 15.2 μM), both consisting of the geranyl group, were found to show relatively strong activities against HSC-4 cells and their mechanisms of action were found to involve apoptotic cell death.
Volume 148
Pages 104780
Published 2021-1-1
DOI 10.1016/j.fitote.2020.104780
PII S0367-326X(20)30362-2
PMID 33246033
MeSH Antineoplastic Agents, Phytogenic / isolation & purification Antineoplastic Agents, Phytogenic / pharmacology* Apoptosis Carcinoma / drug therapy Carcinoma / pathology Cell Line, Tumor Coumarins / isolation & purification Coumarins / pharmacology* Flowers / chemistry Gastrointestinal Neoplasms / drug therapy Gastrointestinal Neoplasms / pathology* Humans Mammea / chemistry* Molecular Structure Phytochemicals / isolation & purification Phytochemicals / pharmacology Plants, Medicinal / chemistry Thailand
IF 2.527
Human and Animal Cells HSC-2(RCB1945) HSC-4(RCB1902) MKN45(RCB1001) MCF7(RCB1904)