論文 - 詳細
| RRC ID | 63241 |
|---|---|
| 著者 | Hayashi R, Nagato T, Kumai T, Ohara K, Ohara M, Ohkuri T, Hirata-Nozaki Y, Harabuchi S, Kosaka A, Nagata M, Yajima Y, Yasuda S, Oikawa K, Kono M, Kishibe K, Takahara M, Katada A, Hayashi T, Celis E, Harabuchi Y, Kobayashi H. |
| タイトル | Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma. |
| ジャーナル | Oncoimmunology |
| Abstract |
Placenta-specific 1 (PLAC1) is expressed primarily in placental trophoblasts but not in normal tissues and is a targetable candidate for cancer immunotherapy because it is a cancer testis antigen known to be up-regulated in various tumors. Although peptide epitopes capable of stimulating CD8 T cells have been previously described, there have been no reports of PLAC1 CD4 helper T lymphocyte (HTL) epitopes and the expression of this antigen in head and neck squamous cell carcinoma (HNSCC). Here, we show that PLAC1 is highly expressed in 74.5% of oropharyngeal and 51.9% of oral cavity tumors from HNSCC patients and in several HNSCC established cell lines. We also identified an HTL peptide epitope (PLAC131-50) capable of eliciting effective antigen-specific and tumor-reactive T cell responses. Notably, this peptide behaves as a promiscuous epitope capable of stimulating T cells in the context of more than one human leukocyte antigen (HLA)-DR allele and induces PLAC1-specific CD4 T cells that kill PLAC1-positive HNSCC cell lines in an HLA-DR-restricted manner. Furthermore, T-cells reactive to PLAC131-50 peptide were detected in the peripheral blood of HNSCC patients. These findings suggest that PLAC1 represents a potential target antigen for HTL based immunotherapy in HNSCC. |
| 巻・号 | 10(1) |
| ページ | 1856545 |
| 公開日 | 2020-12-29 |
| DOI | 10.1080/2162402X.2020.1856545 |
| PII | 1856545 |
| PMID | 33457076 |
| PMC | PMC7781841 |
| MeSH | Antigens, Neoplasm / genetics Epitopes, T-Lymphocyte / genetics Female Head and Neck Neoplasms* / genetics Humans Male Placenta Pregnancy Pregnancy Proteins* Squamous Cell Carcinoma of Head and Neck / genetics T-Lymphocytes, Helper-Inducer |
| IF | 5.869 |
| リソース情報 | |
| ヒト・動物細胞 | HSC-3(RCB1975) HSC-4(RCB1902) LU65(RCB1967) Sa3(RCB0980) EBC-1(RCB1965) |