論文 - 詳細
| RRC ID | 63284 |
|---|---|
| 著者 | Yaku K, Palikhe S, Izumi H, Yoshida T, Hikosaka K, Hayat F, Karim M, Iqbal T, Nitta Y, Sato A, Migaud ME, Ishihara K, Mori H, Nakagawa T. |
| タイトル | BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities. |
| ジャーナル | Nat Commun |
| Abstract |
Nicotinamide riboside (NR) is one of the orally bioavailable NAD+ precursors and has been demonstrated to exhibit beneficial effects against aging and aging-associated diseases. However, the metabolic pathway of NR in vivo is not yet fully understood. Here, we demonstrate that orally administered NR increases NAD+ level via two different pathways. In the early phase, NR was directly absorbed and contributed to NAD+ generation through the NR salvage pathway, while in the late phase, NR was hydrolyzed to nicotinamide (NAM) by bone marrow stromal cell antigen 1 (BST1), and was further metabolized by the gut microbiota to nicotinic acid, contributing to generate NAD+ through the Preiss-Handler pathway. Furthermore, we report BST1 has a base-exchange activity against both NR and nicotinic acid riboside (NAR) to generate NAR and NR, respectively, connecting amidated and deamidated pathways. Thus, we conclude that BST1 plays a dual role as glycohydrolase and base-exchange enzyme during oral NR supplementation. |
| 巻・号 | 12(1) |
| ページ | 6767 |
| 公開日 | 2021-11-19 |
| DOI | 10.1038/s41467-021-27080-3 |
| PII | 10.1038/s41467-021-27080-3 |
| PMID | 34799586 |
| PMC | PMC8604996 |
| MeSH | A549 Cells ADP-ribosyl Cyclase / genetics ADP-ribosyl Cyclase / metabolism* Administration, Oral Aging / drug effects Animals Antigens, CD / genetics Antigens, CD / metabolism* Dietary Supplements GPI-Linked Proteins / genetics GPI-Linked Proteins / metabolism Gastrointestinal Microbiome Glycoside Hydrolases / genetics Glycoside Hydrolases / metabolism* Humans Intestinal Mucosa / metabolism Intestinal Mucosa / microbiology Intestine, Small / metabolism Intestine, Small / microbiology Mice Mice, Knockout Niacin / metabolism Niacinamide / administration & dosage Niacinamide / analogs & derivatives* Niacinamide / metabolism Niacinamide / pharmacokinetics Pentosyltransferases / genetics Pentosyltransferases / metabolism Pyridinium Compounds / administration & dosage Pyridinium Compounds / pharmacokinetics* |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 12 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | A549(RCB0098) CACO-2(RCB0988) |
| 実験動物マウス | RBRC01462 RBRC02401 |