論文 - 詳細
| RRC ID | 63422 |
|---|---|
| 著者 | Yoshimura T, Hamada T, Hijioka H, Souda M, Hatanaka K, Yoshioka T, Yamada S, Tsutsui M, Umekita Y, Nakamura N, Tanimoto A. |
| タイトル | PCP4/PEP19 promotes migration, invasion and adhesion in human breast cancer MCF-7 and T47D cells. |
| ジャーナル | Oncotarget |
| Abstract |
Purkinje cell protein (PCP) 4/peptide (PEP) 19 is expressed in Purkinje cells where it has a calmodulin-binding, anti-apoptotic function. We recently demonstrated that PCP4/PEP19 is expressed and inhibit apoptosis in human breast cancer cell lines. In the present study we investigated the role of PCP4/PEP19 in cell morphology, adhesion, migration, and invasion in MCF-7 and T47D human breast cancer cell lines. Knockdown of PCP4/PEP19 reduced the formation of filopodia-like cytoplasmic structures and vinculin expression, and enhanced E-cadherin expression. Activities of migration, invasion, and cell adhesion were also decreased after the knockdown of PCP4/PEP19 in MCF-7 and T47D cells. These results suggested that PCP4/PEP19 promotes cancer cell adhesion, migration, and invasion and that PCP4/PEP19 may be a potential target for therapeutic agents in breast cancer treatment which act by inhibiting epithelial-mesenchymal transition and enhancing apoptotic cell death. |
| 巻・号 | 7(31) |
| ページ | 49065-49074 |
| 公開日 | 2016-8-2 |
| DOI | 10.18632/oncotarget.7529 |
| PII | 7529 |
| PMID | 27384474 |
| PMC | PMC5226490 |
| MeSH | Apoptosis Breast Neoplasms / metabolism* Breast Neoplasms / pathology* Cadherins / metabolism Cell Adhesion Cell Count Cell Line, Tumor Cell Movement Culture Media Epithelial-Mesenchymal Transition Female Gene Expression Regulation, Neoplastic* Humans MCF-7 Cells Neoplasm Invasiveness Nerve Tissue Proteins / metabolism* Polycomb Repressive Complex 1 / metabolism Pseudopodia / metabolism RNA, Small Interfering / metabolism Treatment Outcome Vinculin / metabolism |
| IF | 5.168 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MCF7(RCB1904) |