| RRC ID |
63451
|
| 著者 |
Okudela K, Mitsui H, Woo T, Arai H, Suzuki T, Matsumura M, Kojima Y, Umeda S, Tateishi Y, Masuda M, Ohashi K.
|
| タイトル |
Alterations in cathepsin L expression in lung cancers.
|
| ジャーナル |
Pathol Int
|
| Abstract |
We herein investigated the potential role of cathepsin L in lung carcinogenesis. Lung cancer cell lines and surgically resected tumors were examined for the expression of the cathepsin L protein and copy number alterations in its gene locus. Cathepsin L was stably expressed in bronchiolar epithelial cells. Neoplastic cells expressed cathepsin L at various levels, whereas its expression was completely lost in most of the lung cancer cell lines (63.6%, 7/11) examined. Furthermore, expression levels were lower in a large fraction of lung tumors (69.5%, 139/200) than in bronchiolar epithelia. The expression of cathepsin L was lost in some tumors (16.0%, 32/200). In adenocarcinomas, expression levels were significantly lower in high-grade tumors than in low-grade tumors (one-way ANOVA, P < 0.0500). Copy number alterations were found in 18.0% (36 [32 gain + 4 loss] /200) of lung tumors. No relationship existed between cathepsin L protein expression levels and the copy number of its gene locus (Spearman's rank-order correlation, P = 0.3096). Collectively, these results suggest that the down-regulated expression of cathepsin L, which is caused by an undefined mechanism other than copy number alterations, is involved in the progression of lung adenocarcinomas.
|
| 巻・号 |
66(7)
|
| ページ |
386-92
|
| 公開日 |
2016-7-1
|
| DOI |
10.1111/pin.12424
|
| PMID |
27327955
|
| MeSH |
Adenocarcinoma / physiopathology*
Adenocarcinoma of Lung
Cathepsin L / genetics*
Cell Line, Tumor
Epithelial Cells / pathology
Gene Expression Regulation, Neoplastic*
Humans
Lung / physiopathology
Lung Neoplasms / physiopathology*
|
| IF |
2.11
|
| リソース情報 |
| ヒト・動物細胞 |
LU65(RCB1967) |
