RRC ID 63499
Author Komoda T, Saeki N, Koseki Y, Kiyota H.
Title 12T061A and 12T061C, two new julichrome family compounds, as radical scavengers from Streptomyces sp.
Journal J Gen Appl Microbiol
Abstract We identified two new radical scavengers, 12T061A (1, C19H20O7) and 12T061C (2, C20H22O7), from a culture of the Streptomyces sp. Spectroscopic analysis indicated that these compounds are new julichrome family compounds. Compounds 1 and 2 showed radical-scavenging activity with an ED50 of 370 μM and 18 μM, respectively. Moreover, 1 showed tumor cell growth suppressive activity in HepG2 cells, (IC50: 3.6 μM); however, no suppressive activity was shown in 2 (IC50: > 100 μM).
Volume 62(1)
Pages 1-6
Published 2016-1-1
DOI 10.2323/jgam.62.1
PMID 26923124
MeSH Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification Free Radical Scavengers / chemistry Free Radical Scavengers / isolation & purification* Hep G2 Cells Hepatocytes / drug effects Humans Inhibitory Concentration 50 Spectrum Analysis Streptomyces / metabolism*
IF 1.442
Resource
Human and Animal Cells HepG2