論文 - 詳細
RRC ID | 63499 |
---|---|
著者 | Komoda T, Saeki N, Koseki Y, Kiyota H. |
タイトル | 12T061A and 12T061C, two new julichrome family compounds, as radical scavengers from Streptomyces sp. |
ジャーナル | J Gen Appl Microbiol |
Abstract |
We identified two new radical scavengers, 12T061A (1, C19H20O7) and 12T061C (2, C20H22O7), from a culture of the Streptomyces sp. Spectroscopic analysis indicated that these compounds are new julichrome family compounds. Compounds 1 and 2 showed radical-scavenging activity with an ED50 of 370 μM and 18 μM, respectively. Moreover, 1 showed tumor cell growth suppressive activity in HepG2 cells, (IC50: 3.6 μM); however, no suppressive activity was shown in 2 (IC50: > 100 μM). |
巻・号 | 62(1) |
ページ | 1-6 |
公開日 | 2016-1-1 |
DOI | 10.2323/jgam.62.1 |
PMID | 26923124 |
MeSH | Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification Free Radical Scavengers / chemistry Free Radical Scavengers / isolation & purification* Hep G2 Cells Hepatocytes / drug effects Humans Inhibitory Concentration 50 Spectrum Analysis Streptomyces / metabolism* |
IF | 1.442 |
リソース情報 | |
ヒト・動物細胞 | Hep G2 |