論文 - 詳細
| RRC ID | 63499 |
|---|---|
| 著者 | Komoda T, Saeki N, Koseki Y, Kiyota H. |
| タイトル | 12T061A and 12T061C, two new julichrome family compounds, as radical scavengers from Streptomyces sp. |
| ジャーナル | J Gen Appl Microbiol |
| Abstract |
We identified two new radical scavengers, 12T061A (1, C19H20O7) and 12T061C (2, C20H22O7), from a culture of the Streptomyces sp. Spectroscopic analysis indicated that these compounds are new julichrome family compounds. Compounds 1 and 2 showed radical-scavenging activity with an ED50 of 370 μM and 18 μM, respectively. Moreover, 1 showed tumor cell growth suppressive activity in HepG2 cells, (IC50: 3.6 μM); however, no suppressive activity was shown in 2 (IC50: > 100 μM). |
| 巻・号 | 62(1) |
| ページ | 1-6 |
| 公開日 | 2016-1-1 |
| DOI | 10.2323/jgam.62.1 |
| PMID | 26923124 |
| MeSH | Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification Free Radical Scavengers / chemistry Free Radical Scavengers / isolation & purification* Hep G2 Cells Hepatocytes / drug effects Humans Inhibitory Concentration 50 Spectrum Analysis Streptomyces / metabolism* |
| IF | 1.442 |
| リソース情報 | |
| ヒト・動物細胞 | Hep G2 |