論文 - 詳細
| RRC ID | 63677 |
|---|---|
| 著者 | Hidaka T, Tsubono Y, Hashiya K, Bando T, Pandian GN, Sugiyama H. |
| タイトル | Enhanced nuclear accumulation of pyrrole-imidazole polyamides by incorporation of the tri-arginine vector. |
| ジャーナル | Chem Commun (Camb) |
| Abstract |
The tri-arginine moiety enhanced nuclear accumulation of a 12-ring pyrrole-imidazole polyamide (PIP) without compromising sequence-selectivity and achieved efficient repression of SOX2-downstream genes and HER2 transcription in live cells. This simple vector expands the application of long PIPs in live cells by overcoming the compound delivery problems associated with them. |
| 巻・号 | 56(82) |
| ページ | 12371-12374 |
| 公開日 | 2020-10-21 |
| DOI | 10.1039/d0cc05158f |
| PMID | 32930253 |
| IF | 5.996 |
| リソース情報 | |
| ヒト・動物細胞 | 201B7(HPS0063) |