論文 - 詳細
| RRC ID | 63722 |
|---|---|
| 著者 | Kitano H, Masaoka Y, Mamiya A, Fujiwara Y, Miki T, Hidai C. |
| タイトル | Combination Cancer Therapy of a Del1 Fragment and Cisplatin Enhanced Therapeutic Efficiency In Vivo. |
| ジャーナル | In Vivo |
| Abstract |
BACKGROUND/AIM:Combination cancer therapy is currently under investigation. This study examined the effect of cancer combination therapy using the E3 and C1 (E3C1) domains of developmental endothelial locus-1 (Del1) and cisplatin (CDDP) in murine transplanted tumors. MATERIALS AND METHODS:Mice with transplanted tumors (A431, SCCKN or SCC-4 cells) were injected intraperitoneally with CDDP and injected locally with nonviral plasmid vectors encoding E3C1. Histochemical analysis of the transplanted tumors was then performed to assess the effects on prognosis. RESULTS:The CDDP+E3C1 injected group had reduced tumor growth and longer survival compared to the CDDP injected group. In addition, cell death was observed in the tumor of the CDDP+E3C1 group.. Furthermore, angiogenesis and increased blood vessels were observed together with stromal development. CONCLUSION:The CDDP+E3C1 treatment resulted in improved survival and poor tumor stromal development in mice with transplanted tumors. |
| 巻・号 | 35(2) |
| ページ | 779-791 |
| 公開日 | 2021-1-1 |
| DOI | 10.21873/invivo.12318 |
| PII | 35/2/779 |
| PMID | 33622870 |
| PMC | PMC8045091 |
| MeSH | Animals Antineoplastic Agents* / pharmacology Cisplatin Combined Modality Therapy Genetic Vectors Mice Neoplasms* Neovascularization, Pathologic / genetics |
| IF | 1.541 |
| リソース情報 | |
| ヒト・動物細胞 | SCCKN(RCB0441) |