| RRC ID |
63746
|
| 著者 |
Polouliakh N, Ludwig V, Meguro A, Kawagoe T, Heeb O, Mizuki N.
|
| タイトル |
Alpha-Arbutin Promotes Wound Healing by Lowering ROS and Upregulating Insulin/IGF-1 Pathway in Human Dermal Fibroblast.
|
| ジャーナル |
Front Physiol
|
| Abstract |
Alpha-arbutin (4-hydroxyphenyl alpha-glucopyranoside) is a known inhibitor of tyrosinase in keratinocytes; however, its effect on other genes and pathways in other skin cells has not been thoroughly investigated. In this study, we investigate the mechanism of alpha-arbutin activity in human dermal fibroblast cultures for 48 h. Results showed that the oxidative stress pathway was activated as alpha-arbutin reduced reactive oxygen species. In addition, we found a high possibility of wound healing and the upregulation of the insulin-like growth factor 1 receptor (IFG1R) pathway. We also investigated the role of the NRF2 gene in mediating the alpha-arbutin response. In silico comparative genomics analysis conducted using our original tool, SHOE, suggested transcription factors with a role in tumor suppression and toxicity response as candidates for regulating the alpha-arbutin-mediated pathway.
|
| 巻・号 |
11
|
| ページ |
586843
|
| 公開日 |
2020-1-1
|
| DOI |
10.3389/fphys.2020.586843
|
| PMID |
33250779
|
| PMC |
PMC7672191
|
| IF |
3.367
|
| リソース情報 |
| ヒト・動物細胞 |
NB1RGB(RCB0222) |
