| RRC ID |
6398
|
| Author |
Reece-Hoyes JS, Deplancke B, Barrasa MI, Hatzold J, Smit RB, Arda HE, Pope PA, Gaudet J, Conradt B, Walhout AJ.
|
| Title |
The C. elegans Snail homolog CES-1 can activate gene expression in vivo and share targets with bHLH transcription factors.
|
| Journal |
Nucleic Acids Res
|
| Abstract |
Snail-type transcription factors (TFs) are found in numerous metazoan organisms and function in a plethora of cellular and developmental processes including mesoderm and neuronal development, apoptosis and cancer. So far, Snail-type TFs are exclusively known as transcriptional repressors. They repress gene expression by recruiting transcriptional co-repressors and/or by preventing DNA binding of activators from the basic helix-loop-helix (bHLH) family of TFs to CAGGTG E-box sequences. Here we report that the Caenorhabditis elegans Snail-type TF CES-1 can activate transcription in vivo. Moreover, we provide results that suggest that CES-1 can share its binding site with bHLH TFs, in different tissues, rather than only occluding bHLH DNA binding. Together, our data indicate that there are at least two types of CES-1 target genes and, therefore, that the molecular function of Snail-type TFs is more plastic than previously appreciated.
|
| Volume |
37(11)
|
| Pages |
3689-98
|
| Published |
2009-6-1
|
| DOI |
10.1093/nar/gkp232
|
| PII |
gkp232
|
| PMID |
19372275
|
| PMC |
PMC2699517
|
| MeSH |
Animals
Basic Helix-Loop-Helix Transcription Factors / metabolism
Binding Sites
Caenorhabditis elegans / genetics
Caenorhabditis elegans / metabolism
Caenorhabditis elegans Proteins / metabolism*
DNA-Binding Proteins / metabolism*
Pharynx / metabolism
Promoter Regions, Genetic
Regulatory Elements, Transcriptional
Transcription Factors / metabolism*
Transcriptional Activation*
|
| IF |
11.502
|
| Times Cited |
23
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| C.elegans |
tm509
tm299 |
