Reference - Detail
| RRC ID | 64153 |
|---|---|
| Author | Takai N, Ueda T, Nasu K, Yamashita S, Toyofuku M, Narahara H. |
| Title | Targeting calcium/calmodulin-dependence kinase I and II as a potential anti-proliferation remedy for endometrial carcinomas. |
| Journal | Cancer Lett |
| Abstract |
Calcium/calmodulin-dependent kinase (CaMK) I and II expression in endometrial cancer cells correlates with the malignant potential of this tumor, and CaMKI and II are potential therapeutic targets in endometrial cancer. CaMKI and II expression was significantly associated with PCNA-labeling index, clinical stage, histological grade, the presence of invasion to greater than one-half the myometrium, and clinical outcome. All endometrial cancer cell lines examined were sensitive to the growth-inhibitory effect of KN-93, a membrane-permeant CaMKs-selective inhibitor that is competitive with calmodulin. KN-93 induced the G0/G1 arrest and apoptosis, rising hopes that KN-93 may become a useful treatment for endometrial cancers. |
| Volume | 277(2) |
| Pages | 235-43 |
| Published | 2009-5-18 |
| DOI | 10.1016/j.canlet.2008.12.018 |
| PII | S0304-3835(08)00952-X |
| PMID | 19168280 |
| MeSH | Antineoplastic Agents / pharmacology* Apoptosis / drug effects Benzylamines / pharmacology* Calcium-Calmodulin-Dependent Protein Kinase Type 1 / antagonists & inhibitors* Calcium-Calmodulin-Dependent Protein Kinase Type 1 / metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 2 / antagonists & inhibitors* Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism Calmodulin / metabolism Cell Cycle / drug effects Cell Cycle / physiology Cell Line, Tumor Cell Proliferation / drug effects* Endometrial Neoplasms Female Humans Sulfonamides / pharmacology* |
| IF | 7.36 |
| Resource | |
| Human and Animal Cells | HHUA(RCB0658) |