| RRC ID |
64178
|
| Author |
Sun S, Omar AM, Kim MJ, Phan ND, Chulikhit Y, Awale S.
|
| Title |
Chemical constituents of Thai Piper ribesoides and their antiausterity activities against the PANC-1 human pancreatic cancer cell line.
|
| Journal |
Fitoterapia
|
| Abstract |
A methanolic extract of Thai Piper ribesoides showed preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition, with a PC50 value of 24 μg/mL. Phytochemical investigation of this bio-active extract led to the isolation of six compounds (1-6), including two new polyoxygenated cyclohexane derivatives, named ribesoidones A and B (1 and 2). The structural elucidation of the new compounds was achieved by a combination of HREIMS, NMR, and circular dichroism spectroscopic analyses. Isolated compounds were tested for their antiausterity activity against PANC-1 human pancreatic cancer cell line. Among these, compounds 1, 3, and 4 displayed potent preferential cytotoxic activity with PC50 values of 5.5-7.2 μM. Ribesoidone A (1) was also found to inhibit PANC-1 colony formation under normal nutrient-rich conditions.
|
| Volume |
151
|
| Pages |
104901
|
| Published |
2021-6-1
|
| DOI |
10.1016/j.fitote.2021.104901
|
| PII |
S0367-326X(21)00076-9
|
| PMID |
33794305
|
| MeSH |
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Pancreatic Neoplasms / drug therapy
Pancreatic Neoplasms / pathology*
Phytochemicals / isolation & purification
Phytochemicals / pharmacology
Piper / chemistry*
Plant Stems / chemistry
Thailand
|
| IF |
2.527
|
| Resource |
| Human and Animal Cells |
PANC-1(RCB2095) |
