Reference - Detail
| RRC ID | 64179 |
|---|---|
| Author | Fukuoka M, Fujita H, Numao K, Nakamura Y, Shimizu H, Sekiguchi M, Hohjoh H. |
| Title | MiR-199-3p enhances muscle regeneration and ameliorates aged muscle and muscular dystrophy. |
| Journal | Commun Biol |
| Abstract |
Parabiosis experiments suggest that molecular factors related to rejuvenation and aging circulate in the blood. Here, we show that miR-199-3p, which circulates in the blood as a cell-free miRNA, is significantly decreased in the blood of aged mice compared to young mice; and miR-199-3p has the ability to enhance myogenic differentiation and muscle regeneration. Administration of miR-199 mimics, which supply miR-199-3p, to aged mice resulted in muscle fiber hypertrophy and delayed loss of muscle strength. Systemic administration of miR-199 mimics to mdx mice, a well-known animal model of Duchenne muscular dystrophy (DMD), markedly improved the muscle strength of mice. Taken together, cell-free miR-199-3p in the blood may have an anti-aging effect such as a hypertrophic effect in aged muscle fibers and could have potential as a novel RNA therapeutic for DMD as well as age-related diseases. The findings provide us with new insights into blood-circulating miRNAs as age-related molecules. |
| Volume | 4(1) |
| Pages | 427 |
| Published | 2021-3-29 |
| DOI | 10.1038/s42003-021-01952-2 |
| PII | 10.1038/s42003-021-01952-2 |
| PMID | 33782502 |
| PMC | PMC8007565 |
| MeSH | Aging / physiology* Animals Disease Models, Animal Male Mice Mice, Inbred C57BL Mice, Inbred mdx MicroRNAs / metabolism* Muscle, Skeletal / physiopathology* Muscular Dystrophy, Duchenne / genetics* Muscular Dystrophy, Duchenne / physiopathology Regeneration / genetics Regeneration / physiology* |
| IF | 4.165 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 26 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | C2C12(RCB0987) |