論文 - 詳細
| RRC ID | 6419 |
|---|---|
| 著者 | Shivers RP, Kooistra T, Chu SW, Pagano DJ, Kim DH. |
| タイトル | Tissue-specific activities of an immune signaling module regulate physiological responses to pathogenic and nutritional bacteria in C. elegans. |
| ジャーナル | Cell Host Microbe |
| Abstract |
Microbes represent both an essential source of nutrition and a potential source of lethal infection to the nematode Caenorhabditis elegans. Immunity in C. elegans requires a signaling module comprised of orthologs of the mammalian Toll-interleukin-1 receptor (TIR) domain protein SARM, the mitogen-activated protein kinase kinase kinase (MAPKKK) ASK1, and MAPKK MKK3, which activates p38 MAPK. We determined that the SARM-ASK1-MKK3 module has dual tissue-specific roles in the C. elegans response to pathogens--in the cell-autonomous regulation of innate immunity and the neuroendocrine regulation of serotonin-dependent aversive behavior. SARM-ASK1-MKK3 signaling in the sensory nervous system also regulates egg-laying behavior that is dependent on bacteria provided as a nutrient source. Our data demonstrate that these physiological responses to bacteria share a common mechanism of signaling through the SARM-ASK1-MKK3 module and suggest the co-option of ancestral immune signaling pathways in the evolution of physiological responses to microbial pathogens and nutrients. |
| 巻・号 | 6(4) |
| ページ | 321-30 |
| 公開日 | 2009-10-22 |
| DOI | 10.1016/j.chom.2009.09.001 |
| PII | S1931-3128(09)00310-2 |
| PMID | 19837372 |
| PMC | PMC2772662 |
| MeSH | Animals Bacteria / immunology* Caenorhabditis elegans / immunology* Caenorhabditis elegans / microbiology* Caenorhabditis elegans Proteins / immunology Cytoskeletal Proteins / immunology Immunity, Innate MAP Kinase Kinase 3 / immunology MAP Kinase Kinase Kinase 5 / immunology Nerve Tissue / physiology Receptors, G-Protein-Coupled Signal Transduction* |
| IF | 15.923 |
| 引用数 | 84 |
| WOS 分野 | PARASITOLOGY MICROBIOLOGY VIROLOGY |
| リソース情報 | |
| 線虫 | tm3036 tm1111 |