| RRC ID |
64206
|
| 著者 |
Aoki S, Higuchi K, Isozumi N, Matsui K, Miyamoto Y, Itoh N, Tanaka K, Kobayashi M.
|
| タイトル |
Differentiation in chronic myelogenous leukemia cell K562 by spongean sesterterpene.
|
| ジャーナル |
Biochem Biophys Res Commun
|
| Abstract |
Scalarane-type sesterterpenes, PHC-1-PHC-7, which have been isolated from a marine sponge, increased hemoglobin production in human chronic myelogenous leukemia cell line K562 at the concentration of 0.1-5 microg/ml. PHC-1, the major constituent, induced the expression of glycophorin A and the enucleation for K562 cells. These sesterterpenes were found to induce erythroid differentiation in K562 cells. In addition, PHC-1 induced G1 arrest of the cell cycle of K562 cells.
|
| 巻・号 |
282(2)
|
| ページ |
426-31
|
| 公開日 |
2001-3-30
|
| DOI |
10.1006/bbrc.2001.4588
|
| PII |
S0006-291X(01)94588-7
|
| PMID |
11401476
|
| MeSH |
Animals
Cell Cycle / drug effects
Cell Differentiation / drug effects
Cell Nucleus / drug effects
Erythropoiesis / drug effects
Glycophorins / metabolism
Hemoglobins / biosynthesis
Humans
K562 Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
Magnetic Resonance Spectroscopy
Molecular Structure
Porifera / chemistry
Sesterterpenes
Terpenes / chemistry
Terpenes / isolation & purification
Terpenes / pharmacology*
|
| IF |
2.985
|
| リソース情報 |
| ヒト・動物細胞 |
K562(RCB0027) |
