RRC ID 64299
Author Murayama MA, Arimitsu N, Shimizu J, Fujiwara N, Takai K, Okada Y, Hirotsu C, Takada E, Suzuki T, Suzuki N.
Title Dementia model mice exhibited improvements of neuropsychiatric symptoms as well as cognitive dysfunction with neural cell transplantation.
Journal Exp Anim
Abstract Elderly patients with dementia suffer from cognitive dysfunctions and neuropsychiatric symptoms (NPS) such as anxiety and depression. Alzheimer's disease (AD) is a form of age-related dementia, and loss of cholinergic neurons is intimately associated with development of AD symptoms. We and others have reported that neural cell transplantation ameliorated cognitive dysfunction in AD model mice. It remains largely unclear whether neural cell transplantation ameliorates the NPS of AD. It would be interesting to determine whether NPS correlates with cognitive dysfunctions before and after neural cell transplantation in AD model mice. Based on the revalidation of our previous data from a Morris water maze test, we found that neural cell transplantation improved anxiety and depression significantly and marginally affected locomotion activity in AD mice. A correlation analysis revealed that the spatial learning function of AD mice was correlated with their NPS scores both before and after cell transplantation in a similar manner. In contrast, in the mice subjected to cell transplantation, spatial reference memory function was not correlated with NPS scores. These results suggested the neural cell transplantation in the AD model mice significantly improved NPS to the same degree as cognitive dysfunctions, possibly via distinct mechanisms, such as the cholinergic and GABAergic systems.
Volume 70(3)
Pages 387-397
Published 2021-8-6
DOI 10.1538/expanim.21-0008
PMID 33828024
PMC PMC8390309
MeSH Alzheimer Disease / physiopathology* Animals Anxiety / physiopathology* Cognitive Dysfunction / physiopathology* Depression / physiopathology* Disease Models, Animal Locomotion* Mice Neural Stem Cells / transplantation* Neuropsychological Tests Spatial Learning*
IF 1.574
Human and Animal Cells 253G1(HPS0002)