RRC ID 64331
著者 Hozumi A, Matsunobu S, Mita K, Treen N, Sugihara T, Horie T, Sakuma T, Yamamoto T, Shiraishi A, Hamada M, Satoh N, Sakurai K, Satake H, Sasakura Y.
タイトル GABA-Induced GnRH Release Triggers Chordate Metamorphosis.
ジャーナル Curr Biol
Abstract Metamorphosis, a widespread life history strategy in metazoans, allows dispersal and use of different ecological niches through a dramatic body change from a larval stage [1, 2]. Despite its conservation and importance, the molecular mechanisms underlying its initiation and progression have been characterized in only a few animal models. In this study, through pharmacological and gene functional analyses, we identified neurotransmitters responsible for metamorphosis of the ascidian Ciona. Ciona metamorphosis converts swimming tadpole larvae into vase-like, sessile adults. Here, we show that the neurotransmitter GABA is a key regulator of metamorphosis. We found that gonadotropin-releasing hormone (GnRH) is a downstream neuropeptide of GABA. Although GABA is generally thought of as an inhibitory neurotransmitter, we found that it positively regulates secretion of GnRH through the metabotropic GABA receptor during Ciona metamorphosis. GnRH is necessary for reproductive maturation in vertebrates, and GABA is an important excitatory regulator of GnRH in the hypothalamus during puberty [3, 4]. Our findings reveal another role of the GABA-GnRH axis in the regulation of post-embryonic development in chordates.
巻・号 30(8)
ページ 1555-1561.e4
公開日 2020-4-20
DOI 10.1016/j.cub.2020.02.003
PII S0960-9822(20)30176-7
PMID 32220316
MeSH Animals Base Sequence Ciona / genetics Ciona / growth & development Ciona / physiology* Gonadotropin-Releasing Hormone / chemistry Gonadotropin-Releasing Hormone / genetics* Gonadotropin-Releasing Hormone / metabolism Metamorphosis, Biological / genetics* gamma-Aminobutyric Acid / metabolism*
IF 9.601
リソース情報
カタユウレイボヤ・(ニッポンウミシダ) gnrh1>Kaede gnrh2>Kaede pHTB>GABABR1 TALEN R1 pHTB>GABAARa TALEN L1 pHTB>GABAARa TALEN R1 pHTB>GABAARb TALEN L1 pHTB>GABAARb TALEN R1 pHTB>PC2 TALEN L1 pHTB>PC2 TALEN R1 pHTB>gnrh2 TALEN L1 pHTB>gnrh2 TALEN R1 pHTB>gnrh1 TALEN L1 pHTB>gnrh1 TALEN R1 pHTB>gnrh1 TALEN L2 pHTB>gnrh1 TALEN R2 pHTB>gnrh1 TALEN L3 pHTB>gnrh1 TALEN R3 GABABR2>H2B::mCherry pEF1>GABABR1 TALEN L1 pEF1>GABABR1 TALEN R1 pEF1>GABAARa TALEN L1 pEF1>GABAARa TALEN R1 pEF1>GABAARb TALEN L1 pEF1>GABAARb TALEN R1 pEF1>PC2 TALEN L1 pEF1>PC2 TALEN R1 pEF1>gnrh2 TALEN L1 pEF1>gnrh2 TALEN R1 pEF1>gnrh1 TALEN L1 pEF1>gnrh1 TALEN R1 pEF1>gnrh1 TALEN L2 pEF1>gnrh1 TALEN R2 pEF1>gnrh1 TALEN L3 pEF1>gnrh1 TALEN R3 pHTB>GABABR1 TALEN L1