RRC ID 64343
Author Inoue N, Nishizumi H, Ooyama R, Mogi K, Nishimori K, Kikusui T, Sakano H.
Title The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli.
Journal Elife
Abstract In mice, early exposure to environmental odors affects social behaviors later in life. A signaling molecule, Semaphorin 7A (Sema7A), is induced in the odor-responding olfactory sensory neurons. Plexin C1 (PlxnC1), a receptor for Sema7A, is expressed in mitral/tufted cells, whose dendrite-localization is restricted to the first week after birth. Sema7A/PlxnC1 signaling promotes post-synaptic events and dendrite selection in mitral/tufted cells, resulting in glomerular enlargement that causes an increase in sensitivity to the experienced odor. Neonatal odor experience also induces positive responses to the imprinted odor. Knockout and rescue experiments indicate that oxytocin in neonates is responsible for imposing positive quality on imprinted memory. In the oxytocin knockout mice, the sensitivity to the imprinted odor increases, but positive responses cannot be promoted, indicating that Sema7A/PlxnC1 signaling and oxytocin separately function. These results give new insights into our understanding of olfactory imprinting during the neonatal critical period.
Volume 10
Published 2021-3-29
DOI 10.7554/eLife.65078
PII 65078
PMID 33780330
PMC PMC8007213
MeSH Animals Antigens, CD / genetics* Antigens, CD / metabolism Female Male Mice Mice, Knockout Nerve Tissue Proteins / genetics* Nerve Tissue Proteins / metabolism Olfactory Perception / genetics* Olfactory Receptor Neurons / physiology* Receptors, Cell Surface / genetics* Receptors, Cell Surface / metabolism Semaphorins / genetics* Semaphorins / metabolism Signal Transduction / genetics*
IF 7.08
Mice RBRC02189 RBRC02933