| RRC ID |
64355
|
| Author |
Ojiro I, Nishio H, Yamazaki-Ito T, Nakano S, Ito S, Toyohara Y, Hiramoto T, Terada Y, Ito K.
|
| Title |
Trp-Trp acts as a multifunctional blocker for human bitter taste receptors, hTAS2R14, hTAS2R16, hTAS2R43, and hTAS2R46.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
Many functional food ingredients activate human bitter taste receptors (hTAS2Rs). In this study, A novel inhibitor, Trp-Trp, for hTAS2R14 was identified by searching for the agonist peptide's analogs. Trp-Trp also inhibited hTAS2R16, hTAS2R43, and hTAS2R46, which share the same agonists with hTAS2R14. The multi-functional characteristic of Trp-Trp is advantageous for use as bitterness-masking agents in functional foods.
|
| Volume |
85(6)
|
| Pages |
1526-1529
|
| Published |
2021-5-25
|
| DOI |
10.1093/bbb/zbab061
|
| PII |
6223520
|
| PMID |
33844825
|
| MeSH |
Dipeptides / pharmacology*
Functional Food / analysis
Humans
Receptors, G-Protein-Coupled / antagonists & inhibitors*
Taste / drug effects
|
| IF |
1.516
|
| Resource |
| Human and Animal Cells |
293T(RCB2202) |
