論文 - 詳細
| RRC ID | 64363 |
|---|---|
| 著者 | Hendaoui I, Lahmar A, Campo L, Mebarki S, Bichet S, Hess D, Degen M, Kchir N, Charrada-Ben Farhat L, Hefaiedh R, Ruiz C, Terracciano LM, Tucker RP, Hendaoui L, Chiquet-Ehrismann R. |
| タイトル | Tenascin-W Is a Novel Stromal Marker in Biliary Tract Cancers. |
| ジャーナル | Front Immunol |
| Abstract |
Extrahepatic cancers of the biliary system are typically asymptomatic until after metastasis, which contributes to their poor prognosis. Here we examined intrahepatic cholangiocarcinomas (n = 8), carcinomas of perihilar bile ducts (n = 7), carcinomas of the gallbladder (n = 11) and hepatic metastasis from carcinomas of the gallbladder (n = 4) for the expression of the extracellular matrix glycoproteins tenascin-C and tenascin-W. Anti-tenascin-C and anti-tenascin-W immunoreactivity was found in all biliary tract tumors examined. Unlike tenascin-C, tenascin-W was not detected in normal hepatobiliary tissue. Tenascin-W was also expressed by the cholangiocarcinoma-derived cell line Huh-28. However, co-culture of Huh-28 cells with immortalized bone marrow-derived stromal cells was necessary for the formation and organization of tenascin-W fibrils in vitro. Our results indicate that tenascin-W may be a novel marker of hepatobiliary tumor stroma, and its absence from many normal tissues suggests that it may be a potential target for biotherapies. |
| 巻・号 | 11 |
| ページ | 630139 |
| 公開日 | 2020-1-1 |
| DOI | 10.3389/fimmu.2020.630139 |
| PMID | 33692777 |
| PMC | PMC7937617 |
| MeSH | Biliary Tract Neoplasms / immunology* Biliary Tract Neoplasms / pathology Biomarkers, Tumor / immunology* Cell Line, Tumor Humans Neoplasm Proteins / immunology* Stromal Cells / immunology Stromal Cells / pathology Tenascin / immunology* |
| IF | 5.085 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | TKKK(RCB1907) TFK-1(RCB2537) TGBC1TKB(RCB1129) TGBC2TKB(RCB1130) TGBC14TKB(RCB1186) TGBC24TKB(RCB1196) G-415(RCB2640) |